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Amphibian DeclinesThe Conservation Status of United States Species$
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Michael Lannoo

Print publication date: 2005

Print ISBN-13: 9780520235922

Published to California Scholarship Online: March 2012

DOI: 10.1525/california/9780520235922.001.0001

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PRINTED FROM CALIFORNIA SCHOLARSHIP ONLINE (www.california.universitypressscholarship.com). (c) Copyright University of California Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CALSO for personal use.date: 02 July 2022

Lucké Renal Adenocarcinoma

Lucké Renal Adenocarcinoma

(p.96) Seventeen Lucké Renal Adenocarcinoma
Amphibian Declines

Robert G. Mckinnell

Debra L. Carlson

University of California Press

The Lucké renal adenocarcinoma of northern leopard frogs (Rana pipiens) was originally described by Balduin Lucké during the 1930s. The depletion of frog populations has been a major concern of herpetologists worldwide. One study has investigated the cell biology of the Lucké renal adenocarcinoma since 1958. Early in these studies, it became obvious that the best way to obtain frog renal adenocarcinomas for experimental studies was to study frogs in natural populations. In retrospect, it seems curious that an investigation into the cell biology of a frog neoplasm would lead to early recognition of frog population declines. The history of the Lucké renal adenocarcinoma of northern leopard frogs is impressive in that these studies led to the notions that herpesviruses can cause cancer, that there was a problem with frog populations in the upper Midwest, and that differentiation therapy may lead to a new form of cancer treatment. This chapter reviews past and present investigations of the Lucké renal adenocarcinoma that afflicts northern leopard frogs. It examines the pathology, epidemiology, and etiology of the Lucké renal adenocarcinoma.

Keywords:   Lucké renal adenocarcinoma, northern leopard frogs, Rana pipiens, Balduin Lucké, cell biology, population declines, differentiation therapy, pathology, epidemiology, etiology

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