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Experimental EvolutionConcepts, Methods, and Applications of Selection Experiments$
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Print publication date: 2009

Print ISBN-13: 9780520247666

Published to California Scholarship Online: March 2012

DOI: 10.1525/california/9780520247666.001.0001

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PRINTED FROM CALIFORNIA SCHOLARSHIP ONLINE (www.california.universitypressscholarship.com). (c) Copyright University of California Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CALSO for personal use.date: 19 September 2021

Through a Glass, Clearly

Through a Glass, Clearly

Experimental Evolution as a Window on Adaptive Genome Evolution

(p.352) (p.353) 13 Through a Glass, Clearly
Experimental Evolution

Frank Rosenzweig

Gavin Sherlock

University of California Press

This chapter explores recent examples where experimental evolution, empowered by genomic technologies and increasingly informed by systems biology, has fundamentally advanced our understanding of adaptive evolution. It focuses on genomically enabled insights into the following issues: how prevalent adaptive parallelism is; what the relative contributions of structural versus regulatory mutations are to the adaptive process; whether trade offs inevitably result from pleiotropy; how and why loss of function occurs under strong selection; and how much and how often adaptations arise from large-scale structural changes, such as gene duplications, deletions, and translocations. The chapter also offers perspective on how whole-genome sequencing and bioinformatics have been and can be fruitfully applied in the context of experimental evolution.

Keywords:   experimental evolution, genomic technologies, systems biology, adaptive evolution, mutations, trade offs, pleiotropy, adaptations, whole-genome sequencing, bioinformatics

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