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Experimental EvolutionConcepts, Methods, and Applications of Selection Experiments$
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Print publication date: 2009

Print ISBN-13: 9780520247666

Published to California Scholarship Online: March 2012

DOI: 10.1525/california/9780520247666.001.0001

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Experimental Evolution from the Bottom Up

Experimental Evolution from the Bottom Up

(p.66) (p.67) 4 Experimental Evolution from the Bottom Up
Experimental Evolution

Daniel E. Dykhuizen

Anthony M. Dean

University of California Press

This chapter focuses on the bottom-up approach used to understand the nature of natural selection, and begins by discussing a bottom-up analysis of the lactose system. The study of lactose metabolism by Escherichia coli provides a tractable experimental system where mechanistic predictions about the direction and intensity of selection can be tested decisively. The chapter also illustrates other ways in which bottom-up experiments in evolution can be done. They can be used to study glucose metabolism in Drosophila and the genotype-phenotype map for single genes. The bottom-up approach can also be used to examine the similarities and differences in vision for organisms in different environments.

Keywords:   bottom-up approach, natural selection, lactose metabolism, Escherichia coli, glucose metabolism, Drosophila

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