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Sequence AlignmentMethods, Models, Concepts, and Strategies$
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Michael Rosenberg

Print publication date: 2009

Print ISBN-13: 9780520256972

Published to California Scholarship Online: March 2012

DOI: 10.1525/california/9780520256972.001.0001

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Computing Multiple Sequence Alignment with Template-Based Methods

Computing Multiple Sequence Alignment with Template-Based Methods

Chapter:
(p.54) (p.55) Chapter 4 Computing Multiple Sequence Alignment with Template-Based Methods
Source:
Sequence Alignment
Author(s):

Cédric Notredame

Publisher:
University of California Press
DOI:10.1525/california/9780520256972.003.0004

This chapter examines the major approaches for multiple sequence alignment (MSA), including matrix- and consistency-based approaches, and focuses on the latest developments, including the development of meta-methods and the emergence of template-based alignment techniques. It also considers the effect of reference benchmarks on the recent development of MSA packages, and their potential shortcomings.

Keywords:   multiple sequence alignment, MSA, matrix-based approaches, consistency-based approaches, meta-methods, template-based alignment

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