The black-tailed prairie dog, the most abundant of four prairie dog species in the United States, had shrunk in number to perhaps 2 percent of its original population and continued to decline because of plague and poisoning. This chapter describes the attempts to protect and conserve prairie dogs. The National Wildlife Federation, a respected mainstream conservation group, had submitted a petition to list the black-tailed prairie dog as a threatened species. Most states agreed to work in a loose organization called the Interstate Black-tailed Prairie Dog Conservation Team. However, campaigns about the prairie dog's destructiveness sold their eradication to the public. In 2004 an incumbent U.S. senator from South Dakota fell to a challenger who built a platform partly on prairie dog control. That same year the U.S. Fish and Wildlife Service dropped the black-tailed prairie dog from its list of candidate species.