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Exposed ScienceGenes, the Environment, and the Politics of Population Health$
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Sara Shostak

Print publication date: 2013

Print ISBN-13: 9780520275171

Published to California Scholarship Online: January 2017

DOI: 10.1525/california/9780520275171.001.0001

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PRINTED FROM CALIFORNIA SCHOLARSHIP ONLINE (www.california.universitypressscholarship.com). (c) Copyright University of California Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CALSO for personal use.date: 28 June 2022

Susceptible Bodies

Susceptible Bodies

(p.71) Three Susceptible Bodies
Exposed Science

Sara Shostak

University of California Press

Chapter 3 describes the development of environmental genomics, which seeks to explain how genetic differences betweenindividuals shape susceptibility to the harmful effects of environmental exposures. It provides a short historical overview of how physicians and scientists have conceptualized the variable susceptibility of human bodies both to diseases and to the drugs used to treat them. In the twentiethcentury, scientists used research on individual variation in drug metabolism, in particular, to molecularize these ways of thinking about bodily differences and extend their relevance to environmental chemicals. At the NIEHS, this line of research has been institutionalized in the Environmental Genome Project. The chapterconcludes by examining the practical, ethical, and policy conundrums raised by environmental genomics.

Keywords:   environmental genomics, genetic susceptibility, drug metabolism, molecularization, NIEHS, environmental genome project, ethics

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