This chapter begins a response to the questions of what creates the unique system of egg donation regulations by examining the ways that stakeholders—legislators, advocates, scientists, and invested citizens—frame the issue of egg donation in reproduction and research. I explore one policy area of egg donation politics in the United States, compensation in California, New York, Arizona, and Louisiana between 1990 and 2010. This chapter explores and illuminates framing processes about egg donation through explaining the method of policy narrative analysis, case selection, and political contexts in each state.